IDENTIFICATION OF SUMOYLATION SITES IN CCDC6, THE FIRST IDENTIFIED RET PARTNER GENE IN PAPILLARY THYROID CARCINOMA, UNCOVERS A MODE OF REGULATING CCDC6 FUNCTION ON CREB1 TRANSCRIPTIONAL ACTIVITY.

CCDC6 was originally identified in chimeric genes as caused by chromosomal translocation involving the RET protooncogene in some thyroid tumors.Recognised as a 65 kDa pro-apoptotic phosphoprotein, CCDC6 has been enrolled as an ATM substrate that contribute to fr6738 protect genome integrity by modulating PP4c activity in response to genotoxic stres

The present study attempts to represent the behavior of shallow foundations under the effectof eccentric inclined loading in terms of the main criteria of design which are the ultimate bearingcapacity, permissible settlement, horizontal displacement and tilt.Due to the square shape of the analysed foundations, three dimensional finite element analy

Accurate and reliable photovoltaic (PV) cell parameter identification is critical telemarkskongen flue to simulation analysis, maximum output power harvest, and optimal control of PV systems.However, inherent high-nonlinear and multi-modal characteristics usually result in thorny obstacles to hinder conventional optimization methods to obtain a fas

Wire electric discharge machining (WEDM) promise to be effective and economical techniques for the production of tools and parts from conducting ceramic blanks.However, the manufacturing of nanocomposite ceramics blanks with redken shades eq dark chocolate these processes is a long and costly process.This paper presents a new process of machining n

Background and Objectives: Religious behaviors, among which Trust in the Almighty God is a major representation, play a key role in giving meaning to life, generation of hope, and mental relaxation.The present study was conducted aimed at examination of the subject Trust in the Almighty God and analysis of the concept Trust from the perspective of